5,6-Dihydro-2-hydroxy-3,9,10-trimethoxydibenzo[a,g]quinolizinium
Columbamine
CAS: 3621-36-1
Molecular Formula: [C20H20NO4]+.
5,6-Dihydro-2-hydroxy-3,9,10-trimethoxydibenzo[a,g]quinolizinium - Names and Identifiers
5,6-Dihydro-2-hydroxy-3,9,10-trimethoxydibenzo[a,g]quinolizinium - Physico-chemical Properties
| Molecular Formula | [C20H20NO4]+. |
| Molar Mass | 338.38 |
| Melting Point | 280-282℃ (methanol ) |
| Solubility | Soluble in methanol, slightly soluble in water |
| Appearance | Yellow needle crystal |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| MDL | MFCD01546522 |
| Physical and Chemical Properties | Orange-yellow crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from tomato roots, leaves, green fruit content is high, low mature fruit. |
5,6-Dihydro-2-hydroxy-3,9,10-trimethoxydibenzo[a,g]quinolizinium - Reference
| Reference Show more | 1. Shi Yuehua, fan Huisen, Liu Xiao, et al. Study on compatibility mechanism of Coptis-fructus mume drug pair in Xiaoai Jiedu prescription based on chemical composition and intestinal flora [J]. Journal of Nanjing University of Traditional Chinese Medicine, 2019, v.35(02):84-89. 2. Lin Caizhi, Zhang Yuyun, Duan Xuelin, etc. Analysis of anti-HBV active components in zhuangyao Xinji platform and its effect on HBV DNA and HBV cccDNA [J]. Pharmacology and Clinic of traditional Chinese medicine, 2018, v.34;No.193(01):59-64. 3. Lin Caizhi, Xie Haiyuan, Huang Zhenqing, etc. Effects of the active ingredients of zhuangyao Xinji Grubin and African Tetrandrine on the promoter of HBV [J]. Pharmacology and Clinic of traditional Chinese medicine, 2019, 035(004):72-77. 4. Wang Xin, Yuan Jinfeng, Peng Shitao, Zhang Yufan, Wang Lei, Zhang Xianling, Li Fei. Comparison of the factors affecting the content of alkaloids in Rhizoma coptidis ginger processing by various statistical methods [J]. World Science and Technology-modernization of traditional Chinese medicine, 2018,20(02):265-271. 5. Song Hongwei, Mao Rui, Li Lihong, et al. Study on multi-component quality control of Rhizoma corydalis before and after processing [J]. Journal of Tianjin University of Traditional Chinese Medicine, 2019, 038(001):63-67. 6. Yan Qi, Li Li, Juanjuan, et al. Simultaneous determination of seven components in the root of altissima nigricans by HPLC [J]. Chinese herbal medicine, 42 Vol. 7, 2020-1588 p. M. 7. Yang Liu, Yin Xiu-Wen, Prince Yu, etc. Study on biopharmaceutics classification system of Coptis chinensis extracts [J]. Chinese Journal of Traditional Chinese Medicine, 2017, 21(v.42):87-94. 8. Zhang Xiaoyu, Li Jia. Simultaneous determination of seven effective components in the wind of gold thread by HPLC-ESI-MS/MS [J]. Chinese Journal of Traditional Chinese Medicine, 2017,32(06):2762-2764. 9. Yan: Yu, Zhang: Yu. Simultaneous determination of five components in jinguolan by HPLC-ESI-MS/MS [J]. Chinese herbal medicines, 2017, 40(002):395-398. 10. Li hearing, Li Meng, Zhang Zhi, et al. Quality Evaluation of Coptis chinensis and its processed products based on high performance liquid chromatography fingerprint and infrared spectroscopy [J]. Central South pharmacy, 2019, 017(004):556-560. 11. Zhang Jiuxu, Fan Jing, Li Xiaoyang, et al. Study on processing method of modern producing area of Coptis chinensis based on internal quality [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2019, v.21;No.185(09):74-77. 12. Zhang Xiao, Zhang Yali, Miao Xiangzhen, etc. Correlation between anti-tumor activity of different processed products and components of Coptis chinensis and content of six alkaloids [J]. Chinese Journal of Traditional Chinese Medicine, 2019, v.34(06):350-353. 13. Li Feng Zhang Zhi, et al. Determination of six alkaloids in different decoction pieces by one-Test multi-evaluation method [J]. Journal of Pharmaceutical Analysis, 2018, 038(007):1132-1138. 14. Kang nianxin, Yuan Yanyan, Zhang Xiao, Lu Yinhui, Li Qingxia, Li Fei, Tan Peng. Establishment of HPLC characteristic chromatogram of alcoholic Coptis chinensis and its cluster analysis and principal component analysis [J]. World Science and Technology-modernization of traditional Chinese medicine, 2020,22(08):2790-2798. 15. Ji Wanli, Zhou Zehua, Wang Tingting, an Yi, Liang Yi, Wang Xinhong. Analysis of chemical constituents of banxia Xiexin decoction based on UPLC-LTQ-Orbitrap-MS method [J]. Journal of Pharmaceutical Analysis, 2020,40(10):1736-1750. 16. Dong, Qian, et al. "In vitro and in vivo bacterial activity of Tinospora sagittata (Oliv.) gagnep. var. craveniana (SY Hu) Lo and its main effective component, palmatine, against porcine Helicobactor pylori." BMC complete and alternative medicine 1 17. Wang, Kun, et al. "Identification of berberrubine metabolites in rats by using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry." Fitoterapia 124 (2018): 23-33.https://doi.org/10.1016/j.fitote.2017.10.00 18. Xu, Jun. "Improved approaches and strategies for analyzing decoctions of medicinal herbs." (2016). 19. Wang, Kun, et al. "Identification of metabolites of palmatine in rats after oral administration using ultra‐high‐performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry." Rapid Communications in Mass Spectrometry 31.6 (2017): 523-537. 20. Wang, Kun, et al. "Metabolites identification of berberine in rats using ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry." Journal of pharmaceutical and biomedical analysis 139 (2017): 73-86.https://doi.org/10.1016/ 21. [IF=4.759] Lvhuan Wang et al."Online screening of acetylcholinesterase inhibitors in natural products using monolith-based immobilized capillary enzyme reactors combined with liquid chromatography-mass spectrometry."J Chromatogr A. 2018 Aug;1563:135 22. [IF=4.411] Jinjun Shan et al."Liquid Chromatography Coupled with Linear Ion Trap Hybrid OrbitrapMass Spectrometry for Determination of Alkaloids in Sinomeniumacutum."Molecules. 2018 Jul;23(7):1634 23. [IF=3.935] Kun Wang et al."Metabolites identification of berberine in rats using ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry."J Pharmaceut Biomed. 2017 May;139:73 24. [IF=2.882] Kun Wang et al."Identification of berberrubine metabolites in rats by using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry."Fitoterapia. 2018 Jan;124:23 25. [IF=2.419] Kun Wang et al."Identification of metabolites of palmatine in rats after oral administration using ultra-high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry."Rapid Commun Mass Sp. 2017 Mar;31(6):523-537 26. [IF=1.618] Li Jiang-Yan et al."Seasonal Variation of Alkaloid Contents and Anti-Inflammatory Activity of Rhizoma coptidis Based on Fingerprints Combined with Chemometrics Methods."J Chromatogr Sci. 2015 Aug;53(7):1131-1139 27. [IF=3.963] Zhong-min Zhao et al."Anti-phytopathogenic activity and the possible mechanisms of action of isoquinoline alkaloid sanguinarine."Pestic Biochem Phys. 2019 Sep;159:51 28. [IF=3.463] Xiao-Meng Liu et al."Comparative transcriptome analysis provides novel insights into molecular mechanism of berberine biosynthesis in Coptis chinensis."Sci Hortic-Amsterdam. 2022 Jan;291:110585 29. [IF=1.345] Ya-Li Zhang et al."Coptisine suppresses proliferation and inhibits metastasis in human pancreatic cancer PANC-1 cells."J Asian Nat Prod Res. 2020;22(5):452-463 |
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Multiple Specifications
Product Name: Jatrorrhizine Impurity 1 Request for quotationCAS: 3621-36-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Columbamine Visit Supplier Webpage Request for quotationCAS: 3621-36-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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